Herpes zoster - Šindre
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U rezultatima Stiftung Warentest-a za 2022. iz Njemačke, zadovoljstvo potrošača ModelDerm-om bilo je samo nešto niže nego s plaćenim telemedicinskim konsultacijama.
Herpes zoster – plikovi na vratu i ramenima.
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ReferencesŠindre, uzrokovane reaktivacijom virusa varicella‑zoster, odgovornog za vodene kozice, pogađaju oko milijun ljudi godišnje u Sjedinjenim Državama, s životnim rizikom od 30 %. Osobe s oslabljenim imunološkim sistemom znatno su sklonije razvoju herpesa, pri čemu simptomi obično počinju malaksalošću, glavoboljom i blagom temperaturom, a zatim slijede neobični osjećaji na koži nekoliko dana prije pojave osipa. Osip, koji se obično pojavljuje na određenom dijelu tijela, napreduje od prozirnih plikova do ranica s krunom tijekom jedne do deset dana. Brzo liječenje antivirusnim lijekovima (acyclovir, valacyclovir, famciclovir) unutar 72 sata od pojave osipa ključno je. Postherpetična neuralgija, uobičajena komplikacija koju karakterizira produljeni bol u zahvaćenom području, pogađa otprilike jednog od pet pacijenata i zahtijeva kontinuirano liječenje lijekovima poput gabapentina, pregabalina ili određenih antidepresiva, uz lokalne pripravke poput lidokaina ili kapsaicina. Vakcinacija protiv virusa varicella‑zoster preporučuje se odraslima starijim od 50 godina kako bi se smanjio rizik od šindre.
Shingles, caused by the reactivation of the varicella zoster virus responsible for chickenpox, affects around 1 million people annually in the United States, with a lifetime risk of 30%. Those with weakened immune systems are significantly more prone to developing shingles, with symptoms typically starting with malaise, headache, and a mild fever, followed by unusual skin sensations a few days before the appearance of a rash. This rash, usually appearing in a specific area of the body, progresses from clear blisters to crusted sores over a week to ten days. Prompt treatment with antiviral medications (acyclovir, valacyclovir, or famciclovir) within 72 hours of rash onset is crucial. Postherpetic neuralgia, a common complication characterized by prolonged pain in the affected area, affects about one in five patients and requires ongoing management with medications such as gabapentin, pregabalin, or certain antidepressants, along with topical agents like lidocaine or capsaicin. Vaccination against the varicella zoster virus is recommended for adults aged 50 and above to reduce the risk of shingles.
Shingles, caused by the reactivation of the varicella zoster virus responsible for chickenpox, affects around 1 million people annually in the United States, with a lifetime risk of 30%. Those with weakened immune systems are significantly more prone to developing shingles, with symptoms typically starting with malaise, headache, and a mild fever, followed by unusual skin sensations a few days before the appearance of a rash. This rash, usually appearing in a specific area of the body, progresses from clear blisters to crusted sores over a week to ten days. Prompt treatment with antiviral medications (acyclovir, valacyclovir, or famciclovir) within 72 hours of rash onset is crucial. Postherpetic neuralgia, a common complication characterized by prolonged pain in the affected area, affects about one in five patients and requires ongoing management with medications such as gabapentin, pregabalin, or certain antidepressants, along with topical agents like lidocaine or capsaicin. Vaccination against the varicella zoster virus is recommended for adults aged 50 and above to reduce the risk of shingles.
Herpes zoster se češće javlja kod osoba starijih od 50 godina, kod onih s oslabljenim imunološkim sistemom i kod osoba koje uzimaju imunosupresivne lijekove. Uzrok je reaktivacija virusa varicella‑zoster, istog virusa koji izaziva vodene kozice. Simptomi poput groznice, bola i svraba obično prethode pojavi karakterističnog osipa. Najčešća komplikacija je post‑herpetična neuralgija – uporna bol u živcima koja traje i nakon što osip nestane. Faktori rizika i komplikacije povezane s herpes zosterom variraju ovisno o dobi, imunološkom stanju i vremenu početka liječenja. Pokazalo se da vakcinacija kod osoba starijih od 60 godina značajno smanjuje pojavu herpes zona i post‑herpetične neuralgije. Početak primjene antivirusnih i analgetičkih lijekova u roku od 72 sata od pojave osipa može smanjiti težinu i komplikacije herpes zona i post‑herpetične neuralgije.
Herpes zoster tends to occur more frequently in people aged 50 and older, those with weakened immune systems, and those taking immunosuppressant medications. It's triggered by the reactivation of the varicella-zoster virus, the same virus that causes chickenpox. Symptoms like fever, pain, and itching commonly precede the appearance of the characteristic rash. The most common complication is post-herpetic neuralgia, which is persistent nerve pain after the rash clears up. The risk factors and complications associated with herpes zoster vary depending on age, immune health, and timing of treatment initiation. Vaccination for individuals aged 60 and above has been shown to significantly reduce the occurrence of herpes zoster and post-herpetic neuralgia. Starting antiviral medications and pain relievers within 72 hours of rash onset can lessen the severity and complications of herpes zoster and post-herpetic neuralgia.
Herpes zoster tends to occur more frequently in people aged 50 and older, those with weakened immune systems, and those taking immunosuppressant medications. It's triggered by the reactivation of the varicella-zoster virus, the same virus that causes chickenpox. Symptoms like fever, pain, and itching commonly precede the appearance of the characteristic rash. The most common complication is post-herpetic neuralgia, which is persistent nerve pain after the rash clears up. The risk factors and complications associated with herpes zoster vary depending on age, immune health, and timing of treatment initiation. Vaccination for individuals aged 60 and above has been shown to significantly reduce the occurrence of herpes zoster and post-herpetic neuralgia. Starting antiviral medications and pain relievers within 72 hours of rash onset can lessen the severity and complications of herpes zoster and post-herpetic neuralgia.
Klinička ispitivanja prije odobrenja pokazuju da živa vakcina protiv zoster‑a djeluje u rasponu od 50 % do 70 %, dok rekombinantna vakcina ima veći učinak – od 90 % do 97 %. Realne studije potvrđuju ove nalaze, pokazujući da je živa vakcina efikasna oko 46 %, a rekombinantna oko 85 %.
The pre-licensure clinical trials show the efficacy of the live zoster vaccine to be between 50 and 70% and for the recombinant vaccine to be higher at 90 to 97%. Real-world effectiveness studies, with a follow-up of approximately 10 years, were reviewed in this article. These data corroborated the efficacy studies, with vaccine effectiveness being 46% and 85% for the live and recombinant vaccines, respectively.
The pre-licensure clinical trials show the efficacy of the live zoster vaccine to be between 50 and 70% and for the recombinant vaccine to be higher at 90 to 97%. Real-world effectiveness studies, with a follow-up of approximately 10 years, were reviewed in this article. These data corroborated the efficacy studies, with vaccine effectiveness being 46% and 85% for the live and recombinant vaccines, respectively.
Ako se lezije brzo šire, posjetite liječnika što je prije moguće radi antivirusnog liječenja. Potrebni su i antivirusni lijekovi i lijekovi za neuralgiju. Trebalo bi da se odmarate i da izbjegavate alkohol.
#Acyclovir
#Fancyclovir
#Valacyclovir
#Gabapentin
#Pregabalin